Peg Doxozest 50mg Injection

Introduction Of Peg Doxozest 50mg Injection

Peg Doxozest 50mg Injection is an anticancer medication that belongs to the class of anthracycline topoisomerase inhibitors that contains the active compound doxorubicin encapsulated in a closed lipid sphere (liposome) in which the liposomes are coated with polyethylene glycol (PEG).

This coating with PEG enhances the circulation of the drug in the bloodstream that helps to deliver the drug from blood stream to cancerous cells rather than healthy ones.

This medication is used as a monotherapy for patients with metastatic breast cancer, with an increased cardiac risk associated with conventional doxorubicin, ovarian cancer, AIDS-related Kaposi’s sarcoma and in combinational therapy of multiple myeloma (cancer of white blood cells called plasma cells).

Therapeutic Effects of Peg Doxozest 50mg Injection

Polyethylene glycol (PEG)-coated liposomes allow enhanced tumor targeting and selective drug release within cancer cells. Doxorubicin, once internalized by cancer cells, intercalates into DNA strands and inhibits transcription and DNA replication, as well as disrupting the topoisomerase II enzymes that are important in DNA repair processes. This causes cancer cells to undergo apoptosis, cell cycle arrest, and DNA damage. Furthermore, doxorubicin produces reactive oxygen species (ROS), which exacerbates oxidative stress and accelerates the death of tumor cells.

The unique formulation process of Peg Doxozest 50mg Injection increases the time this medicine is circulating in the blood. It also helps deliver drugs from blood to the cancerous tissue rather than the healthy tissue.

Interaction of Peg Doxozest 50mg Injection with other drugs

Inform your doctor about any medications you take or have taken before the treatment, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with pegylated liposomal doxorubicin and can cause undesirable side effects.

More Information about Peg Doxozest 50mg Injection

Keep the injection out of sight and reach of children.
Store refrigerated at 2°C – 8°C. Do not freeze.
Protect the medicine from light and excessive moisture.
Keep the medicine out of reach of children and pets.

How to consume Peg Doxozest 50mg Injection

Your doctor will give you an infusion injection (drip) of Peg Doxozest 50mg Injection into a vein. This could take anywhere from 30 minutes to more than an hour, depending on the dosage and condition. Your dose and frequency of administration will be decided by your physician based on your disease condition and other factors. It will be given to you by a healthcare professional. Do not self-administer.

Safety Advices for Peg Doxozest 50mg Injection

Pregnancy

Consult your doctor

Peg Doxozest 50mg Injection may harm the unborn baby and may cause foetal abnormalities. You need to tell your physician if you are pregnant or planning to get pregnant before taking this medicine.

Breast Feeding

Consult your doctor

It is not recommended to nurse a child while taking Peg Doxozest 50mg as the drug passes through breast milk. You need to tell your physician if you are breastfeeding before taking this medicine.

Lungs

Consult your doctor

It is unknown whether Peg Doxozest 50mg can be given to patients with lung diseases. Please consult your physician if you have any lung problems.

Liver

Consult your doctor

It is unknown whether Peg Doxozest 50mg may interact with patients with liver disease. You need to tell your physician if you have any liver disorders before taking this medication.

Alcohol

Unsafe

It is not known whether it is safe to consume alcohol with Peg Doxozest 50mg.

Driving

Consult your doctor

Peg Doxozest 50mg may cause tiredness or sleepiness. Avoid driving and operating machinery if you are unwell.

Side Effects of Peg Doxozest 50mg Injection

Serious

Severe diarrhea, sores in mouth, nausea, vomiting
Hand foot syndrome
Lung infections, shortness of breath
Severe stomach pain

Common

Low blood cell counts
Hair loss
Decreased appetite
Skin rashes

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