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Peg Doxozest 50mg Injection
Pegylated Liposomal Doxorubicin
Uses of Peg Doxozest 50mg Injection
- Metastatic Breast cancer
- Ovarian cancer
- Multiple myeloma
- AIDS-related Kaposi’s sarcoma
Product Description
Introduction to Peg Doxozest 50mg Injection
Peg Doxozest 50mg Injection is an anticancer medication that belongs to the class of anthracycline topoisomerase inhibitors that contains the active compound doxorubicin encapsulated in a closed lipid sphere (liposome) in which the liposomes are coated with polyethylene glycol (PEG).
This coating with PEG enhances the circulation of the drug in the bloodstream that helps to deliver the drug from blood stream to cancerous cells rather than healthy ones. This medication is used as a monotherapy for patients with metastatic breast cancer, with an increased cardiac risk associated with conventional doxorubicin, ovarian cancer, AIDS-related Kaposi’s sarcoma and in combinational therapy of multiple myeloma (cancer of white blood cells called plasma cells).
It is not recommended to use this drug if you are allergic to the active compound pegylated liposomal doxorubicin and its components. It is also not recommended for use if you are allergic to products like pea and soy. It is not recommended for use in children and adolescents aged below 18 years.
It can be used in geriatric patients with dosage adjustments made based on age and body weight. The use of pegylated liposomal doxorubicin is not recommended if you are pregnant or nursing a child. Use effective birth control during the treatment and for at least six months after the last dose. Pegylated liposomal doxorubicin may cause heart diseases. The drug should be administered carefully in patients with a history of cardiovascular disease, and cardiac function should be monitored regularly during the therapy.
It is important to tell your doctor if you are receiving medicines for heart or liver disorders, have diabetes, Kaposi’s sarcoma or oral problems before taking Peg Doxozest 50mg Injection. Inform your physician about all the medications you take including herbal, over the counter medicines and supplements.
Therapeutic Effects of Peg Doxozest 50mg Injection
Polyethylene glycol (PEG)-coated liposomes allow enhanced tumor targeting and selective drug release within cancer cells. Doxorubicin, once internalized by cancer cells, intercalates into DNA strands and inhibits transcription and DNA replication, as well as disrupting the topoisomerase II enzymes that are important in DNA repair processes. This causes cancer cells to undergo apoptosis, cell cycle arrest, and DNA damage. Furthermore, doxorubicin produces reactive oxygen species (ROS), which exacerbates oxidative stress and accelerates the death of tumor cells.
The unique formulation process of Peg Doxozest 50mg Injection increases the time this medicine is circulating in the blood. It also helps deliver drugs from blood to the cancerous tissue rather than the healthy tissue.
Interaction of Peg Doxozest 50mg Injection with other drugs
Inform your doctor about any medications you take or have taken before the treatment, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with pegylated liposomal doxorubicin and can cause undesirable side effects.
More Information about Peg Doxozest 50mg Injection
- Keep the injection out of sight and reach of children.
- Store refrigerated at 2°C – 8°C. Do not freeze.
- Protect the medicine from light and excessive moisture.
- Keep the medicine out of reach of children and pets.
How to consume Peg Doxozest 50mg Injection
Your doctor will give you an infusion injection (drip) of Peg Doxozest 50mg Injection into a vein. This could take anywhere from 30 minutes to more than an hour, depending on the dosage and condition. Your dose and frequency of administration will be decided by your physician based on your disease condition and other factors. It will be given to you by a healthcare professional. Do not self-administer.
Safety Advices for Peg Doxozest 50mg Injection
Pregnancy
Peg Doxozest 50mg Injection may harm the unborn baby and may cause foetal abnormalities. You need to tell your physician if you are pregnant or planning to get pregnant before taking this medicine.
Breast Feeding
It is not recommended to nurse a child while taking Peg Doxozest 50mg Injection as the drug passes through breast milk. You need to tell your physician if you are breastfeeding before taking this medicine.
Lungs
It is unknown whether Peg Doxozest 50mg Injection can be given to patients with lung diseases. Please consult your physician if you have any lung problems.
Liver
It is unknown whether Peg Doxozest 50mg Injection may interact with patients with liver disease. You need to tell your physician if you have any liver disorders before taking this medication.
Alcohol
It is not known whether it is safe to consume alcohol with Peg Doxozest 50mg Injection. Please consult your doctor for further queries.
Driving
Peg Doxozest 50mg Injection may cause tiredness or sleepiness. Avoid driving and operating machinery if you are unwell. Please consult your doctor for more advice.
Side Effects of Peg Doxozest 50mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Serious
- Severe diarrhea, sores in mouth, nausea, vomiting
- Hand foot syndrome
- Lung infections, shortness of breath
- Severe stomach pain
- Seizures
- Severe weakness
- Tachycardia
Common
- Low blood cell counts
- Hair loss
- Decreased appetite
- Skin rashes
- Pain in the muscles and joints
- Constipation
- Conjunctivitis
- Feeling confused, difficulty sleeping
- Headache, dizziness, sleepiness
- Change in taste
- High or low blood pressure
- Excessive sweating
- Pain when passing urine
- Weight loss
- Muscle spasms
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